Quinoline derivatives which are 5-hydroxytryptamine antagonists

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United States of America Patent

PATENT NO 4607039
SERIAL NO

06488607

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Compounds of the formula: ##STR1## wherein A stands for the radical --(CH.sub.2).sub.2 -- which may optionally be substituted by one or two (1-2C)alkyl radicals; Q stands for an oxygen or sulphur atom; R.degree. stands for a (1-4C)alkyl, (1-4C)alkoxy or cyclopropyl radical; R.sup.1 stands for a defined (3-4C)alkyl radical, a phenyl radical which may optionally bear a defined substituent, or a defined heteroaryl radical of 5 or 6 ring atoms; and R.sup.2 and R.sup.3 stand for hydrogen or a (1-2C)alkyl radical; and pharmaceutically-acceptable acid-addition salts thereof. Processes for the manufacture of said compounds. Pharmaceutical compositions comprising one of said compounds and a pharmaceutical diluent or carrier. The compounds are 5-hydroxytryptamine antagonists.

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Patent Owner(s)

  • IMPERIAL CHEMICAL INDUSTRIES PLC

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Le, Count David J Congleton, GB 3 17
Pearce, Robert J Wilmslow, GB 16 164

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