Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites
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United States of America Patent
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Sep 2, 1986
Issued Date -
N/A
app pub date -
Mar 20, 1984
filing date -
Mar 20, 1984
priority date (Note) -
Expired
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Abstract
A process for exposing live cells to a soluble bone protein and transferring the cells into appropriate skeletal sites to initiate or enhance local chondrogenesis or osteogenesis. Isogenic fibroblasts are exposed in vitro to a soluble bone protein capable of stimulating in vitro and/or in vivo a chondrogenic response. The fibroblasts are then transferred in vivo in a manner effective to prevent diffusion away from the implantation site so that the desired chondro/osteogenesis reaction can proceed. Delivery systems include: combining the activated fibroblasts with a biodegradable matrix; suspending the activated fibroblasts in a solution suitable for intra-articular injection; and attaching the fibroblasts to allografts and prosthetic devices.
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