Novel organoplatinum(II) complexes and method for the preparation thereof
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United States of America Patent
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Sep 30, 1986
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N/A
app pub date -
Mar 18, 1985
filing date -
Jan 31, 1983
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Abstract
Amino-substituted-malonato platinum(II) complexes represented by the gene formula L.sub.2 Pt.sup.II (OCO).sub.2 CH--NH.sub.2 wherein L and L.sub.2 are monodentate and bidentate aliphatic amine ligands respectively. Typical examples of L and L.sub.2 are: NH.sub.3, ethylendiamine, 1,2-diaminocyclohexane, ethylenimine, and cyclopropyl-, cyclobutyl-, cyclopentyl-, cyclohexyl-, isopropyl-, n-propyl-amine. The compounds are characterized by high antitumor activity in mice, chemical stability and solubility in aqueous fluids for i.v. administration. The invention provides also a preferred method for their preparation.
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