Particulate NMR contrast agents for gastrointestinal application
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United States of America Patent
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Oct 7, 1986
Grant Date -
N/A
app pub date -
Nov 14, 1983
filing date -
Nov 14, 1983
priority date (Note) -
Expired
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Abstract
Contrast media compositions for nuclear magnetic resonance (NMR) imaging of the gastrointestinal system are provided for oral or rectal administration. The compositions comprise aqueous suspensions of particles of an NMR contrast agent, the particles being very finely-divided and providing in their outer surfaces a substantially water-insoluble paramagnetic compound. Suspending and/or wetting agents may be included to maintain the contrast agent particles in a dispersed, suspended condition for the oral or rectal administration. Buffering agents may also be included to maintain the pH of the suspension in a pH range protecting the insolubility of the paramagnetic compound.
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