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Abstract

For producing the bone substitute material from collagen and hydroxyapatite, an aqueous solution of cleaned collagen is mixed with a cross-linking agent causing only a partial cross-linking, and the mixture is lyophilized. The quantity of the cross-linking agent is chosen such that the collagen retains its resorbability and its absorptivity vis-a-vis bodily fluids, the material further showing no undesirable side effects. Preferably less than 1% by weight of formaldehyde, one of the preferred cross-linking agents, is added, with reference to the dry weight of collagen, and sintered apatite grains with a diameter of 50-300 .mu.m are used. Such a bone substitute material is stronger and less tearable as previously known materials and insures a good promotion of the growth of own bone tissue and the substitution by it.

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First Claim