Method of producing prefilled sterile plastic syringes
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United States of America Patent
Stats
-
Dec 16, 1986
Grant Date -
N/A
app pub date -
Dec 20, 1985
filing date -
Dec 20, 1985
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
There is disclosed a process for producing sterilized prefilled plastic syringes avoiding plastic deformation and distortion. The plastic barrels are subjected to repeated water jet washing steps to remove contaminants and depyrogenate the barrels. Tip seals and pistons are subjected to washing, autoclaving and rinsing steps to remove contaminants and depyrogenate. After the tip is assembled on the nozzle of the barrel, the barrel is filled with contrast media through its open end, after which the piston is assembled in the open end to seal the syringe and its contents. The assembled and sealed syringe is then subjected to autoclaving to sterilize the syringe and its contents, without deformation of the plastic syringe or a loss of integrity to the closed media/syringe system.
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