Detecting and distinguishing between plasminogen activators
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United States of America Patent
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Dec 16, 1986
Grant Date -
N/A
app pub date -
Jul 12, 1983
filing date -
Jul 12, 1983
priority date (Note) -
Expired
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Abstract
This invention relates to a method for determining fibrinolytic activation in human blood and to a method to distinguish between tissue (e.g. vascular) plasminogen activator and urokinase-like plasminogen activator contributions to fibrinolytic activation. Broadly, the method of the invention relates to detecting the level of plasmin-plasmin inhibitor complexes in blood plasma samples before and after clotting thereof; a greater increase in the complex level in the clotted sample as compared to non-clotted samples indicating the presence of circulating tissue plasminogen activator, with substantially identical levels of increase of complex in both the clotted and unclotted samples indicating the sole presence of urokinase-type plasminogen activator in the sample.
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