Synthesis of cyclopropane amino acids
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United States of America Patent
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Dec 16, 1986
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N/A
app pub date -
Dec 5, 1984
filing date -
Aug 16, 1983
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Expired
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Abstract
Cyclopropane ('Cyclopropyl') amino acids and peptides containing at least one cyclopropyl amino acid are disclosed. The processes for synthesizing cyclopropyl amino acids and peptides containing at least one cyclopropyl amino acid are also disclosed. Cyclopropyl amino acids are useful as enzyme inhibitors and as substitutes for natural amino acids in peptide hormones such as regulators of bodily functions to enhance bioactivity, to stabilize the peptide into which it is incorporated to cleavage by enzymes and to convert such peptides into enzyme inhibitors.
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