Transdermal delivery of highly ionized fat insoluble drugs
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United States of America Patent
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Feb 24, 1987
Grant Date -
N/A
app pub date -
May 3, 1985
filing date -
May 3, 1985
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A medical device for the transdermal delivery of highly ionized, fat insoluble drugs comprises an aqueous drug reservoir having a physiological pH, said reservoir preferably being a gel maintained in an impermeable receptacle by a highly permeable support member disposed between the gel and a permeable contact adhesive. A permeation enhancer reservoir delivers a permeation enhancer to the skin through the aqueous reservoir and through a permeation enhancer release rate controlling membrane which is permeable to the permeation enhancer and impermeable to the drug and water. In a preferred embodiment the permeation enhancer release rate controlling membrane forms at least a portion of said receptacle.
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