Method of continuous production of retroviruses (HTLV-III) from patients with AIDS and pre-AIDS
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United States of America Patent
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Mar 3, 1987
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N/A
app pub date -
Apr 23, 1984
filing date -
Apr 23, 1984
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Abstract
A cell system is disclosed for the reproducible detection and isolation of human T-lymphotropic retroviruses (HTLV-family) with cytopathic effects (HTLV-III) from patients with the acquired immune deficiency syndrome (AIDS), pre-AIDS and in healthy carriers. One neoplastic aneuploid T-cell line derived from an adult with lymphoid leukemia, and termed HT, was susceptible to infection with the new variants of HTLV, which are transformed and providing T-cell populations which are highly susceptible and permissive from HTLV-III, and convenience for large scale production, isolation and biological detection of the virus.
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