Peptides with relaxin activity
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United States of America Patent
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Apr 7, 1987
Grant Date -
N/A
app pub date -
Jun 10, 1982
filing date -
Jun 10, 1982
priority date (Note) -
Expired
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Abstract
A method for the synthesis of porcine relaxin or modified forms or analogues thereof, which comprises the steps of reducing a mixed solution of the S-sulfonated A and B peptide chains, or modified forms or analogues thereof; precipitating the reduced peptides with acetone; washing the mixed peptides; oxidizing the mixed peptides in the presence of aqueous sodium chloride; and isolating the relaxin thus produced. Also claimed are modified forms and analogues of porcine relaxin analogues which comprise shortened forms of the natural B and/or A peptide chains, and/or in which one or both of A and B chains in the full length or shortened form has been chemically modified.
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