Molecules with antibody combining sites that bind to hydrolytic transition states
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United States of America Patent
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Apr 21, 1987
Grant Date -
N/A
app pub date -
Sep 7, 1984
filing date -
Sep 7, 1984
priority date (Note) -
Expired
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Abstract
A phosphonamidate or phosphonate analog-ligand having a conformation that substantially corresponds to the conformation of a hydrolytic transition state of an amide or ester ligand is used to produce antibodies of predetermined specificity. The antibodies include an epitope that binds to and thereby stabilizes the tetrahedral carbon atom of the amide or ester hydrolysis transition state of the ligand to hydrolyze the ligand at a predetermined site.
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