Storage-stable, quick-disintegrating pressed shapes containing pharmaceutical active substances
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United States of America Patent
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-
May 19, 1987
Grant Date -
N/A
app pub date -
Mar 13, 1985
filing date -
Mar 23, 1984
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Storage stable, quick-disintegrating pressed shapes containing pharmaceutical active substances, which shapes consist substantially of a compressed mixture of (a) an effective amount of a pharmaceutical active substance in granular form, which is coated with a coating material comprising essentially a homogeneous mixture of a poly(H+meth)-acrylic acid-(methyl+ethyl) ester insoluble but dispersible in water and an ethyl cellulose insoluble but dispersible in water, the weight ratio of the acrylic acid ester to ethyl cellulose being 2.5:1 to 5:1; (b) talcum; and (c) colloidal silicon dioxide, and crosslinked polyvinylpolypyrrolidone as the disintegrating agent having a high disintegrating capacity and good binding properties.
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