Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls
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United States of America Patent
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May 19, 1987
Grant Date -
N/A
app pub date -
Apr 10, 1984
filing date -
Apr 10, 1984
priority date (Note) -
Expired
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Abstract
A method of inhibiting von Willebrand factor binding to human platelets induced with thrombin, ADP, or other stimuli has been developed. The administration of the small molecular weight peptide or the synthetic inhibitory molecule of the invention significantly inhibits thrombin or ADP-modified human platelets binding of von Willebrand factor, a plasma protein necessary for platelet interaction with blood vessels. The method of the invention is useful for inhibiting the formation of hemostatic platelet plugs and the initiation of thrombotic lesions. The blockage caused by hemostatic platelet plugs and the damage caused by thrombotic lesions are major factors in heart disease and stroke. The invention also includes a method of inducing the interaction of platelets with blood vessels by administration of a synthetic platelet reactive molecule.
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