Microencapsulation of living tissue and cells
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United States of America Patent
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-
Jun 16, 1987
Issued Date -
N/A
app pub date -
May 24, 1984
filing date -
Jun 1, 1983
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Living tissue or cells, for example, islets of Langerhans, are microencapsulated for implantation in the body for long term treatment of diabetes or other disease requiring organ transplantation. The microcapsules take the form of a biocompatible semi-permeable hydrogel membrane based on polylysine which permits the passage of materials and oxygen to the cells and metabolic products from the cells while retaining the cells encapsulated. The biocompatible semi-permeable membrane has an outer negatively-charged surface, which, combined with a controlled thickness of polylysine of molecular weight from 10,000 to 30,000 daltons, imparts to the microcapsules the ability to maintain long term effectiveness.
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