Antifungal utility of bile acids
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United States of America Patent
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Jul 21, 1987
Grant Date -
N/A
app pub date -
Jul 15, 1985
filing date -
Jul 13, 1984
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A valuable alternative antifungal antibiotic, for treatment especially of candidiasis, particularly vaginal candidiasis, is proposed. The antibiotic is a bile acid or simple derivative (salt or conjugate) thereof. Cholic, deoxycholic, chenodeoxycholic and lithocholic acid are preferred bile acids. The antibiotic is formulated for topical application. It can be used in association with an anti-inflammatory steroid for the treatment of fungal infections of the skin. It is also proposed to inhibit fungal growth in a variety of pharmaceutical compositions (containing some other active ingredient) by including in the composition, or coating a tablet, pill or capsule with, the bile acid component.
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