Method and composition for regulating serum calcium levels of mammals
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United States of America Patent
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Sep 8, 1987
Issued Date -
N/A
app pub date -
Aug 1, 1985
filing date -
Oct 12, 1983
priority date (Note) -
Expired
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Abstract
Method for regulating serum calcium levels in mammals by orally administering a composition which includes a polypeptide hormone such as parathyroid hormone (PTH) or calcitonin. The polypeptide hormone is protected from destruction in the digestive tract by encapsulation in liposomes. The liposome preferably includes a cationic amphiphilic agent so that the surface of the liposome has a net positive charge. Agents for enhancing the action of the liposome encapsulated hormones are also disclosed.
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