Process for the separation of optical isomers of racemic 1-pyridyl-alkyl-4-aryl piperazines, and optical isomers obtained thereby
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United States of America Patent
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Sep 8, 1987
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N/A
app pub date -
Dec 11, 1985
filing date -
Jul 11, 1983
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Expired
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Abstract
A process for the preparation of 1-pyridyl-alkyl-4-aryl piperazines, in the racemic form, of the formula ##STR1## in which: the pyridine ring is alpha-, beta-, or gamma-substituted; R=H; C.sub.n H.sub.2n+1, n being in the range from 1 to 4; R'=H, halogen, CH.sub.3, OCH.sub.3, in which process: (a) pyridine aldehyde is reacted between -5.degree. C. and 0.degree. C. with (CH.sub.3).sub.2 S=CH.sub.2 ; (b) the oxirane so obtained is treated with an arylpiperzazine; (c) the hydroxyl derivative obtained in (b), after salification with alkalien hydrides or hydrates in a solvent medium is treated with alkylating agents, and the separation of the compounds so obtained into the respective optical antipodes.
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