Bradykinin antagonist peptides
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United States of America Patent
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Sep 15, 1987
Grant Date -
N/A
app pub date -
Jun 13, 1985
filing date -
Jun 13, 1985
priority date (Note) -
Expired
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Abstract
The substitution of the L-Pro at the 7-position of the peptide hormone bradykinin or other substituted analogs of bradykinin with an aromatic amino acid or the D-configuration converts bradykinin agonists into a bradykinin antagonist. The invention further includes additional modifications at other positions within the novel 7-position modified bradykinin antagonists which increase enzyme resistance, antagonist potency and/or specificity of the new bradykinin antagonists. The analogs produced are useful in treating conditions and diseases of the mammal and human body in which an excess of bradykinin or related kinins are produced or injected as by bites into the body.
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