Tumoricidal methotrexate-antibody conjugate
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United States of America Patent
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Oct 13, 1987
Grant Date -
N/A
app pub date -
Feb 25, 1986
filing date -
Feb 25, 1986
priority date (Note) -
Expired
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Abstract
A conjugate of methotrexate to an antibody is prepared by loading methotrexate onto an aminodextran, then specifically conjugating the polymer carrier to the carbohydrate portion of an antitumor antibody, using a reduced Schiff base linkage. The conjugate is useful for tumor targeted therapy.
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