1-Cyclopropyl-1,4-dihydro-4-oxo-7-(4-(2-oxo-1,3-dioxol-4-yl-methyl)-1-piperazinyl)-3-quinolinecarboxylic acid antibacterial agents

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United States of America Patent

PATENT NO 4703047
SERIAL NO

06822714

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Abstract

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Novel antibacterially active 1-cyclopropyl-1,4-dihydro-4-oxo-7-[4-(2-oxo-1,3-dioxol-4-yl-methyl)-1-piperazinyl]-3-quinolinecarboxyic acids of the formula in which ##STR1## R is hydrogen or, together with R.sup.1, forms an alkylene radical with 2 or 3 carbon atoms, R.sup.1 is hydrogen, alkyl with 1 to 4 carbon atom or phenyl, R.sup.2 and R.sup.3 each independently is hydrogen, methyl, ethyl, cyclohexyl, methylene-dioxphenyl, furyl, tetrahydrofuryl or thienyl; or phenyl which is optionally mono-, di or tri-substituted by fluorine, chlorine, bromine, methyl, phenyl, cyano, hydroxyl, ethoxy, benzyloxy, amino, methylamino, dimethylamino, piperidino or nitro, X.sup.1 is hydrogen, halogen, or nitro, and X.sup.2 is hydrogen or halogen, or pharmaceutically acceptable hydrates, acid addition salts, alkali metal salts or alkaline earth metal salts thereof.

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Patent Owner(s)

Patent OwnerAddress
BAYER AKTIENGESELLSCHAFT A CORP OF GERMANYLEVERKUSEN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Grohe, Klaus Odenthal, DE 108 1411
Metzger, Karl G Wuppertal, DE 120 1205
Petersen, Uwe Leverkusen, DE 102 943
Zeiler, Hans-Joachim Velbert, DE 99 1090

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