Transdermal therapeutic system having improved delivery characteristics
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United States of America Patent
Stats
-
Nov 3, 1987
Grant Date -
N/A
app pub date -
Jun 29, 1984
filing date -
Jun 29, 1984
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A transdermal therapeutic system using a subsaturated matrix is provided having improved approved release characteristics. Reinforcing means preferably in the form of a fabric are embedded in the upper surface of the subsaturated matrix. At least a portion of the reinforcing means is selected such that the active agent to be delivered to the skin has a solubility, C.sub.r therein which is lower than the initial solubility C.sub.o of the agent in the matrix. In addition, the relationship between the diffusion coefficients of the agent in the matrix D.sub.m and the portion of reinforcing means D.sub.r and the solubilities is given by the relationship: D.sub.r .multidot.C.sub.r
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