Method of diagnosing cartilage tissue abnormalities

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United States of America Patent

PATENT NO 4704356
SERIAL NO

06594112

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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It is found that abnormal levels of keratan sulfate in the peripheral blood are indicative of abnormalities of cartilage or cartilage-like tissues. Specifically, elevated levels of keratan sulfate in the peripheral blood plasma or serum are indicative of osteoarthritis and either substantially complete absence of or very elevated levels of keratan sulfate in the peripheral blood are indicative of muscular dystrophy and related disorders. The level of keratan sulfate in the peripheral blood is determined by an immunoassay using a monoclonal antibody. Preferably the immunoassay employs a colorimetric reporter system.

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Patent Owner(s)

  • RUSH-PRESBYTERIAN-ST. LUKE'S MEDICAL CENTER;RUSH-PESBYTERIAN-ST. LUKE'S

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Thonar, Eugene J Berwyn, IL 1 28

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