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Abstract

A chromatography column-electrophoresis system for directing the fluid output from the column directly to a point of use, further resolution or separation, detection and/or identification while conditioning or preparing the output for analysis by another instrument such as a mass spectrometer. The system provides for substantially simultaneous analysis in a mass spectrometer, for example, material separated initially by the column, followed by electrophoretic separation and resolution. The chromatography column utilizes horizontal or radial flow of the sample fluid through the separating medium. The column may be of a type having a quickly replaceable or disposable separating medium, or the entire column may be of a readily replaceable or disposable type. The electrophoresis apparatus is of a capillary tube type, one embodiment of which utilizes a pair of capillary tubes thereby providing for continuous operation.

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First Claim