Devices for the controlled release of active substances, as well as process for the preparation thereof
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United States of America Patent
Stats
-
Nov 24, 1987
Grant Date -
N/A
app pub date -
Mar 10, 1986
filing date -
Mar 13, 1985
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
The invention relates to a device for the controlled release of one or more active ingredients to a liquid, particularly a controlled release pharmaceutical tablet obtained by compressing a mixture of two granulates in a weight ratio of 30:70 to 70:30, said granulates having particle sizes of 0.4-2.0 mm. One of the granulates, the restraining phase granulate, comprises one or more active ingredients dispersed in a matrix of an insoluble substance, and the other granulate, the housing phase granulate, comprises a soluble material and a penetration rate limiting material, one material optionally having both functions. In the compressed device, the granulates form two distinct phases, each of which is continuous. The housing phase fills large continuous pores in the restraining phase. A zero-order release rate can be obtained with the devices.
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