Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues
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United States of America Patent
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Dec 15, 1987
Grant Date -
N/A
app pub date -
Mar 12, 1985
filing date -
Mar 12, 1985
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Disclosed is hylan, a chemically modified hyaluronic acid preparation characterized by the presence of small amounts (0.005-0.05% by weight) of aldehyde cross-linking groups covalently bonded to the hyaluronic acid molecular chains. Also disclosed is a method of obtaining hylan comprising treating hyaluronic acid in situ in animal tissues containing same with a treatment mixture including a reagent (typically an aldehyde) which is reactive towards hyaluronic acid and the proteins contained in the animal tissue.
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