Quaternary derivatives of noroxymorphone which relieve nausea and emesis
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United States of America Patent
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Jan 12, 1988
Grant Date -
N/A
app pub date -
Mar 7, 1986
filing date -
Mar 7, 1986
priority date (Note) -
Expired
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Abstract
Quaternary derivatives of noroxymorphone are used to prevent or relieve nausea and emesis associated with the use of narcotic analgesics without interfering with the analgesic activity of the drugs. A particularly preferred compound is methylnaltrexone. The compound is administered in a concentration between 0.25 mg/kg and 1.0 mg/kg prior to or concurrently with the administration of the narcotic analgesic.
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