Novel pharmaceutical compositions containing hydrophobic practically water-insoluble drugs adsorbed on pharmaceutical excipients as carrier; process for their preparation and the use of said compositions
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United States of America Patent
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Jan 26, 1988
Issued Date -
N/A
app pub date -
Aug 4, 1984
filing date -
Jul 26, 1984
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Pharmaceutical compositions are disclosed which contain hydrophobic practically water-insoluble drugs adsorbed onto carriers such as starch and/or microcrystalline cellulose. The rate of dissolution and absorption in the body is improved due to the very fine particle size of the drug adsorbed onto the carriers. The drug particles have a mean size of less than 10 microns the size distribution of particles being such that at least 95% of particles are smaller than 15 microns. A process for the preparation of drug-carrier adsorbates and their incorporation in pharmaceutical compositions is also disclosed. The use of such compositions to treat mammals is also disclosed.
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