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Abstract

A method of treatment of emesis, anxiety and/or IBS in mammals, including humans, which method comprises administering an effective amount of a compound of formula (I) or (II) or a pharmaceutically acceptable salt thereof: Ar--Co--Y--Z (I) wherein Ar is a group of formula (a): ##STR1## wherein: R.sub.1 and R.sub.2 are independently selected from hydrogen, halogen, C.sub.1-6 alkyl, C.sub.1-4 alkoxy, hydroxy, amino optionally substituted by one or two C.sub.1-4 alkyl groups, thiol, C.sub.1-4 alkylthio; X is CH.sub.2, NR.sub.3, --O-- or --S-- wherein R.sub.3 is hydrogen, C.sub.1-4 alkyl, C.sub.3-5 alkenyl, phenyl or phenyl C.sub.1-4 alkyl; or Ar is a group of formula (b): ##STR2## wherein R.sub.4 to R.sub.7 are independently hydrogen, halogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxy, amino optionally substituted by one or two C.sub.1-4 alkyl, by C.sub.1-4 alkanoylamino or pyrrolyl, one of R.sub.4 to R.sub.7 being other than hydrogen; Y is --O-- or --NH--; and Z is a group of formula (c), (d) or (e): ##STR3## wherein n is 2, 3 or 4; R.sub.8 is hydrogen, C.sub.1-7 alkyl, C.sub.3-5 alkenyl or phenyl C.sub.1-4 alkyl optionally substituted by one or two halogen, C.sub.1-4 alkoxy or C.sub.1-4 alkyl; ##STR4## wherein: p is 1, 2 or 3; and R.sub.9 is as defined above for R.sub.8 ; and with the proviso that, when Ar is of formula (b) and Y is --NH--, Z is a group of formula (d) or (e); ##STR5## wherein R.sub.10 is hydrogen, C.sub.1-10 alkyl, C.sub.3-7 cycloalkyl, C.sub.3-6 alkenyl, phenyl or phenyl-C.sub.1-3 alkyl; and one of the groups represented by R.sub.11, R.sub.12 and R.sub.13 is hydrogen, C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, C.sub.2-6 alkenyl or phenyl-C.sub.1-3 alkyl and each of the other groups, which may be the same or different, is hydrogen or C.sub.1-6 alkyl.

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First Claim