Contrast agents for NMR imaging
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United States of America Patent
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-
Mar 1, 1988
Issued Date -
N/A
app pub date -
Apr 10, 1985
filing date -
Apr 27, 1984
priority date (Note) -
Expired
status (Latency Note)
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Abstract
An agent for contrast enhancement in nuclear magnetic resonance imaging is disclosed. Micellular particles such as phospholipid vesicles are associated with or enclose a paramagnetic material. The particles may be formulated with an agent, such as cholestrol, to promote vesicle stability and water exchange across the vesicle bilayer. The vesicles may or may not have antibodies or other cell recognition targeting agents attached to the surface to provide specific targeting. The vesicles provide enhanced target specificity, reduced burden of toxic contrast material and amplified contrast enhancement.
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