Selective incorporation of a polymer into implantable biological tissue to inhibit calcification
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United States of America Patent
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Mar 8, 1988
Grant Date -
N/A
app pub date -
Nov 5, 1985
filing date -
Nov 5, 1985
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A process for selectively incorporating biocompatible polymers in the interstices of implantable biological tissue while leaving the outer surface of the tissue substantially free of bonded polymer. The process involves covalently binding a monomer to the tissue, contacting the tissue with a free-radical initiator, then contacting the tissue with a solution containing a second monomer and a free-radical scavenger, thereby promoting selective polymerization of the second monomer with the portion of covalently-bound first monomer which is located in the interstices of the tissue.
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