Tetrahydro-benzthiazoles, the preparation thereof and their use as intermediate products or as pharmaceuticals

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United States of America Patent

PATENT NO 4731374
SERIAL NO

06810947

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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This invention relates to new tetrahydrobenzthiazoles of general formula ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkyl group, an alkenyl or alkynylk group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the above mentioned phenyl nuclei may each be substituted by 1 or 2 halogen atoms, R.sub.2 represents a hydrogen atom or an alkyl group, R.sub.3 represents a hydrogen atom, an alkyl group a cycloalkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the phenyl nucleus may be substituted by flurorine, chlorine or bromine atoms, R.sub.4 represents a hydrogen atom, an alkyl group, an alkyl or alkenyl group, or R.sub.3 and R.sub.4 together with the nitrogen atom between them represent a pyrrolidino, piperidino, hexamethyleneimino or morpholino group, the enantiomers and the acid addition salts thereof. The compounds of general formula I above in which one of the groups R.sub.1 or R.sub.3 or both groups R.sub.1 and R.sub.3 represent an acyl group are valuable intermediate products for preparing the other compounds of general formula I which have valuable pharmacological properties. The new compounds may be prepared using methods known per se.

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Patent Owner(s)

Patent OwnerAddress
BOEHRINGER INGELHEIM INTERNATIONAL GMBHGERMANY INGELHEIM AM RHEIN RHINELAND-PALATINATE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bauer, Rudolf Wiesbaden, DE 38 1633
Griss, deceased Gerhart late of Biberach, DE 7 187
Hinzen, Dieter Zornheim, DE 15 203
Hurnaus, Rudolf Biberach, DE 36 484
Kobinger, Walter Vienna, AT 26 410
Mierau, Joachim Mainz, DE 30 347
Pichler, Ludwig Vienna, AT 26 266
Schingnitz, Gunter Kreuznach, DE 14 243

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