Sensor having piezoelectric crystal for microgravimetric immunoassays
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United States of America Patent
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Apr 5, 1988
Grant Date -
N/A
app pub date -
Nov 28, 1984
filing date -
Nov 28, 1984
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A sensor and method for performing immunoassays using surface acoustic waves on a piezoelectric crystal is provided. A specific antigen or antibody is bonded to the surface of the piezoelectric crystal and its resonant frequency in a blank solution is determined. The sensor is then exposed to a test solution containing an antigen or antibody corresponding to the substance bonded to the surface of the crystal. As the antigen and antibody react, the resonant frequency of the crystal is altered. This change can be correlated to determine the amount of antigen or antibody in the test solution. A nonreactive reference sensor can also be used to compensate for any nonselective adsorption.
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