Process for the separation of antifactor VIII:C antibodies, more particularly usable for the purification of the blood plasma of a type a hemophiliac
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United States of America Patent
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Apr 5, 1988
Grant Date -
N/A
app pub date -
May 21, 1986
filing date -
May 31, 1985
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The process for the separation of antiVIII:C antibodies present in a liquid consists of contacting said liquid with a solid support constituted by a polymer or a copolymer having in its chain substitutable groups, whereof at least part is substituted by groups having an affinity for antiVIII:C antibodies and a selectivity for antiVIII:C antibodies compared with other immunoglobulins and then separating the liquid from the support on which have been adsorbed the antiVIII:C antibodies. Preferably use is made of polystyrene, to which have been fixed groups --SO.sub.3 Na and --SO.sub.2 Glu, --SO.sub.2 Threo, --SO.sub.2 OHPro or SO.sub.2 Lys. These supports can be used for ex-vivo purification in the column of the blood plasma of a type A hemophiliac.
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