Substitute for human blood and a method of making the same
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United States of America Patent
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Apr 19, 1988
Issued Date -
N/A
app pub date -
Dec 20, 1985
filing date -
Apr 27, 1984
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The method of this invention yields a two phase liquid aqueous system which replicates the two phase heterogeneous physiochemical system of naturally occurring whole human blood. The method produces a composition of matter which comprises a whole blood substitute when polymerized hemoglobin or pyridoxylated-polymerized hemoglobin and preferably, other specific additives are incorporated. When said blood substitute is processed further, a microencapsulated composition with time release characteristics that can transport oxygen is produced. The invention overcomes the obstacles that have prevented the use of modified hemoglobins like pyridoxylated-polymerized hemoglobin in the preparation of oxygen transport systems.
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