Hollow porous microspheres containing biocatalyst
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United States of America Patent
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May 10, 1988
Issued Date -
N/A
app pub date -
Oct 3, 1984
filing date -
Aug 9, 1984
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Biocatalyst such as enzymes or cells are immobilized in hollow porous microspheres for use as bioreactors in biochemical processes. The microspheres are of substantially uniform diameter of 200 to 10,000 microns and of substantially uniform wall thickness of 1 to 1000 microns. Walls of the microspheres are formed of sintered together particles such as inorganic particles. The walls have interconnecting voids that are continuous and extend from outer wall surface to the inner wall surface. The biocatalyst is introduced into the microspheres through macropores in the walls, and then immobilized. Immobilization may be performed by introducing a gel forming material with the biocatalyst and forming a semipermeable gel in situ within the microspheres.
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