Membrane plasmapheresis apparatus and process which utilize a flexible wall to variably restrict the flow of plasma filtrate and thereby stabilize transmembrane pressure
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United States of America Patent
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May 24, 1988
Issued Date -
N/A
app pub date -
Dec 15, 1986
filing date -
Jun 25, 1981
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A membrane plasmapheresis system introduces a flow of whole blood subject to a predetermined inlet pressure into a fluid path across a membrane which is suited for filtering the plasma from the whole blood and across which a predetermined pressure drop occurs. The plasma-poor blood is conducted from the membrane subject to a determinable plasma-poor blood pressure. Likewise, plasma filtrate is conducted from the membrane subject to a determinable plasma-filtrate pressure. The conduction of plasma filtrate is metered in response to the existent plasma-poor blood pressure to achieve and thereafter maintain substantial equilibrium between the plasma-poor blood pressure and the plasma filtrate pressure. A substantially constant transmembrane pressure can thereby be maintained at a level below which hemolysis occurs.
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