Cartilage-derived leukocyte elastase-inhibitor
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United States of America Patent
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May 24, 1988
Grant Date -
N/A
app pub date -
Jul 30, 1986
filing date -
Jul 30, 1986
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A protein or a pharmaceutically acceptable salt thereof. The protein has a molecular weight of 10,000-30,000 Dalton, an isoelectric point greater than 9.5, and an N terminus of the sequence H-Lys-X-Phe-Lys-Val-Asp-Val-Leu-Ala-Ala-Leu-X-Phe-Asn-Ala-, wherein X is an amino acid or a tryptic cleavage product which has the sequence -Gly-Ala-Asn-Ala-Val-Asn-. Methods for the isolation and purification of the protein, compositions containing the protein, and methods for the use of the protein and compositions, are also disclosed.
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