US Patent No: 4,748,023

Number of patents in Portfolio can not be more than 2000

Process for the preparation of sustained release pharmaceutical compositions having a high active ingredient content

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Abstract

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The invention relates to a process for the preparation of sustained release solid pharmaceutical compositions having an active ingredient content of at least 80% and possessing a structure which loosens in aqueous medium but does not disintegrate to discrete particles within 4 hours which comprises coating the particles of the active ingredient in a liquid medium with a water insoluble polymer--preferably with an ethyl cellulose polymer film--and thereafter admixing the coated crystals with at least one disintegrating agent being capable of swelling in aqueous medium and other auxiliary agents conventionally used in pharmaceutical industry and pressing the mixture into tablets. The advantage of the process of the present invention is that it is readily feasible with a very wide range of active ingredients and provides sustained release tablets having a high active ingredient content.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
EGYT GYOGYSZERVEGYESZETI GYARBUDAPEST0
EGYT GYOGYSZERVEGYESZETI GYAR, 30-38, KERESZTURI UT, H-1106 BUDAPEST, HUNGARYBUDAPEST0

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bezzegh, Denes Budapest, HU 6 69
Bor, nee Baumgartner Ilona Budapest, HU 1 48
Fekete, Pal Budapest, HU 13 125
Kovacs, Tibor Szentendre, HU 2 50
Tamas, Eva Godollo, HU 1 48
Toth, Zoltan Budapest, HU 19 131
Zukovics, nee Sumeg Katalin Budapest, HU 3 58

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Sterling Drug Inc. (1)
* 4,415,547 Sustained-release pharmaceutical tablet and process for preparation thereof 54 1982
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (6)
* 5,534,262 Pharmaceutical granulated composition and method for preparing same 7 1993
* 2005/0013,860 Controlled release potassium chloride tablets 7 2003
* 2006/0275,376 Microcapsules with modified release of active principles with low solubility for oral delivery 2 2003
* 2004/0156,899 Formulation of an erodible, gastric retentive oral dosage form using in vitro disintegration test data 52 2004
* 2008/0138,879 METHOD FOR CONTROLLED RELEASE OF ENZYMATIC REACTION COMPONENTS 0 2007
* 2010/0239,665 PHARMACEUTICAL NIMODIPINE COMPOSITIONS 7 2008
 
ALZA CORPORATION (1)
* 4,904,474 Delivery of drug to colon by oral disage form 34 1988
 
CEPHALON, INC. (8)
* 7,229,644 Pharmaceutical formulations of modafinil 4 2002
* 2003/0220,403 Novel pharmaceutical formulations of modafinil 6 2002
* 2008/0058,424 Novel pharmaceutical formulations of modafinil 1 2007
8,268,892 Pharmaceutical formulations of modafinil 1 2008
* 2008/0207,761 Pharmaceutical formulations of modafinil 0 2008
* 2010/0129,444 Novel Pharmaceutical Formulations of Modafinil 0 2010
8,859,621 Pharmaceutical formulations of modafinil 0 2012
8,686,047 Pharmaceutical formulations of modafinil 0 2012
 
ADARE PHARMACEUTICALS, INC. (2)
7,632,521 Controlled release potassium chloride tablets 0 2003
* 2008/0279,937 CONTROLLED RELEASE POTASSIUM CHLORIDE TABLETS 3 2003
 
TORRENT PHARMACEUTICALS LTD. (1)
* 2008/0081,067 SUSTAINED RELEASE PHARMACEUTICAL COMPOSITIONS OF VENLAFAXINE AND PROCESS FOR PREPARATION THEREOF 0 2007
 
NOVARTIS PHARMACEUTICALS CORPORATION (1)
* 6,294,197 Solid oral dosage forms of valsartan 9 1999
 
KADMON PHARMACEUTICALS, LLC (2)
7,538,094 Composition containing ribavirin and use thereof 0 2004
* 2005/0019,406 Composition containing ribavirin and use thereof 4 2004
 
EUROCELTIQUE S.A., 122, BOULEVARD DE LA PETRUSSE, LUXEMBOURG (1)
* 4,844,910 Spheroids 69 1987
 
Nortec Development Associates, Inc. (1)
* 4,938,968 Controlled release indomethacin 20 1988
 
SIGMOID PHARMA LIMITED (12)
* 2008/0113,031 Minicapsule Formulations 28 2005
* 2007/0292,523 Dihydropyrimidine Formulations 9 2005
* 2006/0018,965 Solid oral dosage form containing seamless microcapsules 9 2005
9,114,071 Oral pharmaceutical composition 0 2008
8,911,777 Pharmaceutical composition of tacrolimus 0 2008
8,535,713 Pharmaceutical cyclosporin compositions 1 2008
* 2010/0203,120 PHARMACEUTICAL CYCLOSPORIN COMPOSITIONS 3 2008
8,951,570 Manufacture of multiple minicapsules 0 2008
9,278,070 Composition comprising oil drops 0 2010
9,220,681 Formulations 0 2013
9,387,179 Pharmaceutical cyclosporin compositions 0 2013
9,402,788 Manufacture of multiple minicapsules 0 2014
 
FLAMEL TECHNOLOGIES (9)
7,709,445 Colloidal suspension of nanoparticles based on an amphiphilic copolymer 2 2002
7,910,133 Oral pharmaceutical formulation in the form of aqueous suspension of microcapsules for modified release of amoxicillin 0 2003
* 2006/0110,463 Oral pharmaceutical formulation in the form of aqueous suspension of microcapsules for modified release of amoxicillin 3 2003
* 2004/0138,095 Colloidal suspension of nanoparticles based on an amphiphilic copolymer 12 2004
* 2005/0037,077 Galenic microparticulate oral formulation for delayed and controlled release of pharmaceutical active principles 10 2004
7,659,365 Telechelic homopolyamino acids functionalized with hydrophobic groups, and their applications, especially therapeutic applications 2 2004
* 2007/0265,192 Telechelic Homopolyamino Acids Functionalized with Hydrophobic Groups, and Their Applications, Especially Therapeutic Applications 6 2004
* 2010/0068,291 Oral Medicament Based on a Proton Pump Inhibitor 2 2006
7,678,882 Polyamino acids functionalized by at least one hydrophobic group and the therapeutic application thereof 1 2006
 
DEPOMED, INC. (5)
* 2003/0091,630 Formulation of an erodible, gastric retentive oral dosage form using in vitro disintegration test data 99 2001
* 2003/0104,052 Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract 61 2001
* 2003/0152,622 Formulation of an erodible, gastric retentive oral diuretic 125 2002
7,976,870 Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract 24 2004
* 2004/0185,105 Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract 56 2004
 
Flamel Technologies, Inc. (1)
* 2007/0196,497 Pharmaceutical formulations for the prolonged release of active principle(s) and their applications 28 2004
 
UPSHER-SMITH LABORATORIES, INC. (3)
* 6,780,437 Coated potassium chloride granules and tablets 0 2002
7,056,534 Coated potassium chloride granules and tablets 2 2004
* 2005/0079,219 Coated potassium chloride granules and tablets 1 2004
 
PANACEA BIOTEC LIMITED (1)
* 2009/0088,415 Controlled release pharmaceutical compositions 0 2006
 
Eisai Research Institute (1)
* 2006/0280,789 Sustained release formulations 8 2005
 
APTALIS PHARMATECH, INC. (1)
* 5,651,984 Controlled release potassium tablet 8 1995
 
EISAI R&D MANAGEMENT CO., LTD. (8)
* 5,624,683 Sustained-release multi-granule tablet 3 1994
* 5,576,021 Sustained-release multi-granule tablet 5 1994
* 2009/0208,579 Matrix Type Sustained-Release Preparation Containing Basic Drug or Salt Thereof, and Method for Manufacturing the Same 12 2005
8,481,565 Method for stabilizing anti-dementia drug 0 2005
* 2008/0213,368 Method for Stabilizing Anti-Dementia Drug 1 2005
* 2006/0246,003 Composition containing anti-dementia drug 14 2006
8,507,527 Method for stabilizing anti-dementia drug 0 2010
* 2010/0152,164 Method For Stabilizing Anti-Dementia Drug 0 2010
 
PLIVA, INC. (1)
* 5,407,686 Sustained release composition for oral administration of active ingredient 116 1992
 
FLAMEL IRELAND LIMITED (7)
7,906,145 Oral pharmaceutical formulation in the form of aqueous suspension for modified release of active principle(s) 16 2003
8,652,523 Oral pharmaceutical formulation in the form of a plurality of microcapsules for prolonged release of active principle(s) with slow solubility 0 2003
8,101,209 Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles 12 2004
* 2004/0234,601 Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles 17 2004
8,084,045 Pharmaceutical formulations for the prolonged release of active principle(s) and their applications 0 2004
8,821,935 Microcapsules with modified release of active principles with low solubility for oral delivery 0 2006
* 2007/0160,678 Microcapsules with modified release of active principles with low solubility for oral delivery 5 2006
 
L. Perrigo Company (2)
* 5,773,031 Acetaminophen sustained-release formulation 41 1996
* 6,126,969 Immediate release/sustained release compressed tablets 48 1997
 
AWD.PHARMA GMBH & CO. KG (1)
* 2008/0279,952 Controlled-Release Flupirtine Compositions, Compacts, Kits and Methods of Making and Use Thereof 0 2007
 
SS Pharmaceutical Co., Ltd. (2)
* 5,186,943 Compressed-molded preparations 13 1989
* 5,275,825 Compressed-molded preparations 3 1991
 
Smith Kline & French Laboratories Limited (1)
* 5,169,640 Pharmaceutical compositions 31 1989
 
Nostrum Pharmaceuticals, Inc. (2)
6,437,000 Controlled release oral dosage for suitable for oral administration 15 2000
* 7,179,486 Process for preparing sustained release tablets 8 2001
 
TEVA GmbH (1)
* 2008/0279,930 Controlled-Release Flupirtine Compositions, Compacts, Kits and Methods of Making and Use Thereof 0 2007
 
ABBOTT LABORATORIES (1)
* 5,268,182 Sustained-release drug dosage units of terazosin 22 1992
 
MEDA PHARMA GMBH & CO. KG (1)
* 6,667,058 Oral forms of administration containing solid flupirtine with controlled release of active substance 17 1994
 
YAMANOUCHI EUROPE N.V. (1)
* 5,837,292 Granulate for the preparation of fast-disintegrating and fast-dissolving compositions containing a high amount of drug 10 1996
 
PROMEGA CORPORATION (1)
7,306,929 Method for controlled release of enzymatic reaction components 21 2004
* Cited By Examiner