US Patent No: 4,748,023

Number of patents in Portfolio can not be more than 2000

Process for the preparation of sustained release pharmaceutical compositions having a high active ingredient content

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Importance

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Abstract

The invention relates to a process for the preparation of sustained release solid pharmaceutical compositions having an active ingredient content of at least 80% and possessing a structure which loosens in aqueous medium but does not disintegrate to discrete particles within 4 hours which comprises coating the particles of the active ingredient in a liquid medium with a water insoluble polymer--preferably with an ethyl cellulose polymer film--and thereafter admixing the coated crystals with at least one disintegrating agent being capable of swelling in aqueous medium and other auxiliary agents conventionally used in pharmaceutical industry and pressing the mixture into tablets. The advantage of the process of the present invention is that it is readily feasible with a very wide range of active ingredients and provides sustained release tablets having a high active ingredient content.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
EGYT GYOGYSZERVEGYESZETI GYARBUDAPEST47
EGYT GYOGYSZERVEGYESZETI GYAR, 30-38, KERESZTURI UT, H-1106 BUDAPEST, HUNGARYBUDAPEST1

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bezzegh, Denes Budapest, HU 6 53
Bor, nee Baumgartner Ilona Budapest, HU 1 34
Fekete, Pal Budapest, HU 13 104
Kovacs, Tibor Szentendre, HU 2 36
Tamas, Eva Godollo, HU 1 34
Toth, Zoltan Sunnyvale, CA 16 84
Zukovics, nee Sumeg Katalin Budapest, HU 3 43

Cited Art

Patent Info (Count) # Cites Year
 
STERLING DRUG INC. (1)
4,415,547 Sustained-release pharmaceutical tablet and process for preparation thereof 53 1982

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
FLAMEL TECHNOLOGIES (7)
7,709,445 Colloidal suspension of nanoparticles based on an amphiphilic copolymer 1 2002
7,910,133 Oral pharmaceutical formulation in the form of aqueous suspension of microcapsules for modified release of amoxicillin 0 2003
7,906,145 Oral pharmaceutical formulation in the form of aqueous suspension for modified release of active principle(s) 2 2003
8,101,209 Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles 0 2004
7,659,365 Telechelic homopolyamino acids functionalized with hydrophobic groups, and their applications, especially therapeutic applications 1 2004
8,084,045 Pharmaceutical formulations for the prolonged release of active principle(s) and their applications 0 2004
7,678,882 Polyamino acids functionalized by at least one hydrophobic group and the therapeutic application thereof 1 2006
 
APTALIS PHARMATECH, INC. (2)
5,651,984 Controlled release potassium tablet 7 1995
7,632,521 Controlled release potassium chloride tablets 0 2003
 
CEPHALON, INC. (2)
7,229,644 Pharmaceutical formulations of modafinil 2 2002
8,268,892 Pharmaceutical formulations of modafinil 0 2008
 
EISAI R&D MANAGEMENT CO., LTD. (2)
5,624,683 Sustained-release multi-granule tablet 3 1994
5,576,021 Sustained-release multi-granule tablet 4 1994
 
L. PERRIGO COMPANY (2)
5,773,031 Acetaminophen sustained-release formulation 15 1996
6,126,969 Immediate release/sustained release compressed tablets 24 1997
 
NOSTRUM PHARMACEUTICALS, INC. (2)
6,437,000 Controlled release oral dosage for suitable for oral administration 8 2000
7,179,486 Process for preparing sustained release tablets 3 2001
 
SS PHARMACEUTICAL CO., LTD. (2)
5,186,943 Compressed-molded preparations 9 1989
5,275,825 Compressed-molded preparations 3 1991
 
UPSHER-SMITH LABORATORIES, INC. (2)
6,780,437 Coated potassium chloride granules and tablets 0 2002
7,056,534 Coated potassium chloride granules and tablets 2 2004
 
ABBOTT LABORATORIES (1)
5,268,182 Sustained-release drug dosage units of terazosin 21 1992
 
ALZA CORPORATION (1)
4,904,474 Delivery of drug to colon by oral disage form 31 1988
 
DEPOMED, INC. (1)
7,976,870 Gastric retentive oral dosage form with restricted drug release in the lower gastrointestinal tract 2 2004
 
EUROCELTIQUE S.A., 122, BOULEVARD DE LA PETRUSSE, LUXEMBOURG (1)
4,844,910 Spheroids 33 1987
 
KADMON PHARMACEUTICALS, LLC (1)
7,538,094 Composition containing ribavirin and use thereof 0 2004
 
MEDA PHARMA GMBH & CO. KG (1)
6,667,058 Oral forms of administration containing solid flupirtine with controlled release of active substance 5 1994
 
NORTEC DEVELOPMENT ASSOCIATES, INC. (1)
4,938,968 Controlled release indomethacin 6 1988
 
NOVARTIS PHARMACEUTICALS CORPORATION (1)
6,294,197 Solid oral dosage forms of valsartan 7 1999
 
PLIVA, INC. (1)
5,407,686 Sustained release composition for oral administration of active ingredient 66 1992
 
PROMEGA CORPORATION (1)
7,306,929 Method for controlled release of enzymatic reaction components 1 2004
 
SMITH KLINE & FRENCH LABORATORIES LIMITED (1)
5,169,640 Pharmaceutical compositions 22 1989
 
YAMANOUCHI EUROPE N.V. (1)
5,837,292 Granulate for the preparation of fast-disintegrating and fast-dissolving compositions containing a high amount of drug 9 1996
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (1)
5,534,262 Pharmaceutical granulated composition and method for preparing same 7 1993