Orally active nonaddicting analgesics

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United States of America Patent

PATENT NO 4749706
SERIAL NO

06843150

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Abstract

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Stereoisomerically pure forms of normorphine analogs which have superior analgesic and nonaddicting qualities are described. In addition, a method of separating diastereomeric forms of N-sec-alkyl-substituted analogs utilizes the hydrocarbyl(1-8C) diesters of the normorphine derivatives. A new method for preparing the N-methylalkylmethyl derivatives of normorphine and norcodeine and their conventional analogs is also disclosed. This method employs the corresponding methyl alkyl ketones and a reducing agent.

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Patent Owner(s)

Patent OwnerAddress
PHARMACO DEVELOPMENT PARTNERS 545 MIDDLEFIELD ROADSUITE 180 MENLO PARK CA 94025

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
DeGraw, Joseph I Sunnyvale, CA 14 180
Lawson, John A Fremont, CA 23 354
Loew, Gilda H Atherton, CA 4 38

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