Diabetes control by serotonin

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United States of America Patent

PATENT NO 4761287
SERIAL NO

06849849

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Abstract

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A discovery that insulin alone does not fully control liver function of glucose uptake, release, and synthesize. A second hormone, serotonin, is released in the portal vein as a function of glucose presence in the gut and portal vein. In the absence of the portal serotonin, the liver will not take up and store glucose, and will, in fact, synthesize more glucose. Adult onset diabetics generally do not have a lack of natural insulin. Whenever a serotonin deficiency is the lacking control factor, this hormone is supplied by a hepatocyte diected vesicle (HDV) containing serotonin timed to reach the liver with the supply of glucose from a meal.

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Patent Owner(s)

Patent OwnerAddress
CALFEE HALTER & GRISWOLD LLP800 SUPERIOR AVENUE SUITE 1400 CLEVELAND OH 44114

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Geho, Walter B Wooster, OH 2 103

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