Enkephalinase and endorphinase inhibitors as anti-craving compositions
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United States of America Patent
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Aug 2, 1988
Grant Date -
N/A
app pub date -
Jul 22, 1985
filing date -
Jul 22, 1985
priority date (Note) -
Expired
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Abstract
A new class of anti-craving compositions is provided by substances which inhibit breakdown of endogenous substances such as enkephalins and/or endorphins. An anti-alcohol craving effect is observed with an enkephalin breakdown inhibitor. Specifically, D-phenylalanine, DL-phenylalanine, D-leucine, DL-leucine, and hydrocinnamic acid, each an encephalin breakdown inhibitor, significantly lowered alcohol intake in animals and humans. The anti-alcohol desire effect is observed in animals genetically prone to choose alcohol over water solutions.
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