In vivo cellular tracking
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United States of America Patent
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-
Aug 9, 1988
Grant Date -
N/A
app pub date -
Oct 31, 1986
filing date -
Oct 31, 1986
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Methods of tracking cells in vivo and for determining in vivo cell lifetimes. Cells are labelled with cyanine dyes and detection is by measuring fluorescence, absorbance, or by detecting nuclear magnetic resonance probes included in the cyanine dyes. Using the invented methods, for example, red blood cell and platelet lifetimes are determined. Also, cells are tracked to determine sites of primary or metastatic tumors, or sites of occult infection. Further, rates at which cells pass through vessels is used to determine blood vessel patency and platelet aggregation.
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