Pharmaceutical preparation containing ibuprofen and a process for its preparation
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United States of America Patent
Stats
-
Aug 9, 1988
Grant Date -
N/A
app pub date -
Nov 4, 1985
filing date -
Nov 5, 1984
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A pharmaceutical preparation containing ibuprofen is disclosed. In the preparation, the ibuprofen particles are enveloped by a coating of a hydro-colloid and fumaric acid. Preferably, the hydro-colloid comprises xanthan gum and/or maltodextrin. This preparation reduces the tendency of ibuprofen to irritate the esophagus and the gastrointestinal tract when taken orally. An effervescent mixture of the ibuprofen containing preparation can be prepared by incorporating citric acid and calcium carbonate into the mixture. A process for the manufacture of the ibuprofen containing preparation is also disclosed. In this process, ibuprofen particles are coated with the hydro-colloid and fumaric acid under vacuum conditions in a vacuum mixing machine and the resulting preparation is thereafter vacuum-dried.
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