Complexes of flavanolignans with phospholipids, preparation thereof and associated pharmaceutical compositions
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United States of America Patent
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Aug 16, 1988
Grant Date -
N/A
app pub date -
Jul 7, 1986
filing date -
Jul 17, 1985
priority date (Note) -
Expired
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Abstract
The invention relates to novel compounds comprising lipophilic complexes of silybin, silidianin, and silicristin with phospholipids, and the preparation of these complexes by non-conventional methods. Absorption of the novel compounds in the gastrointestinal tract is appreciably greater, resulting in higher plasma levels than for the individual flavanolignans. The resulting improvement in the pharmacokinetic and pharmacological parameters is such that the substances can advantageously be used in the treatment of acute and chronic liver disease of toxic, metabolic or infective origin or of degenerative nature.
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