Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents
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United States of America Patent
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Sep 13, 1988
Grant Date -
N/A
app pub date -
Jul 3, 1986
filing date -
Jul 3, 1986
priority date (Note) -
Expired
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Abstract
This invention relates to an improved method for obtaining the in vivo MNR image of an organ or tissue of an animal or human subject. More specifically, this invention relates to the use of small (about 10 to about 5,000 angstroms in diameter) biodegradable superparamagnetic metal oxide particles for use as imaging agents. The particles, which may be uncoated or surrounded by a stable polymeric coating, can be mixed with a physiologically acceptable medium to form a uniform dispersoid which can be administered to the subject by a variety of routes. Once administered, the particles collect in the target organ or tissue where they will remain for a time sufficiently long for an image to be obtained, but are ultimately metabolized or cleared within about 7 days.
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