Chiral 3-(1,2,5-trisubstituted imidazolidinone) azetidinone antibiotic intermediates
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United States of America Patent
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Sep 20, 1988
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N/A
app pub date -
Jul 24, 1986
filing date -
Jul 24, 1986
priority date (Note) -
Expired
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Abstract
2,5-Disubstituted oxazolidin-4-one-3-ylacetyl chlorides and 1,2,5-substituted imidazolidin-4-one-3-yl-acetyl chlorides function as chiral auxiliary moieties in the asymmetric cycloaddition with aldimines to provide cis-azetidinones. The azetidinones are useful intermediates in the preparation of antibiotics.
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