Ultrasonic imaging agent and method of preparation
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United States of America Patent
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Oct 4, 1988
Issued Date -
N/A
app pub date -
Oct 1, 1987
filing date -
Dec 5, 1985
priority date (Note) -
Expired
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Abstract
An ultrasonic imaging agent is formed by subjecting an aqueous protein solution to high frequency sonication while heating the solution sufficiently to denature portions of the protein, thereby forming a dispersion of microbubbles stabilized by denatured protein. In a preferred embodiment, the protein solution is formed from human serum albumin, and the formed microbubbles have a relatively uniform size in the 2 to 5 micron range, suitable for imaging of pulmonary or small organ vasculature.
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