US Patent No: 4,775,361

Number of patents in Portfolio can not be more than 2000

Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

A method of administering a therapeutic substance to a human patient, the method having the steps of ablating the stratum corneum of a region of the skin of the patient using pulsed laser light of wavelength, pulse length, pulse energy, pulse number, and pulse repetition rate sufficient to ablate the stratum corneum without significantly damaging the underlying epidermis, and applying the therapeutic substance to the region of ablation.

Loading the Abstract Image... loading....

First Claim

See full text

all claims..

Related Publications

Loading Related Publications... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
THE GENERAL HOSPITAL CORPORATIONBOSTON, MA, US1422

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Blank, Irvin H Belmont, MA 1 116
Jacques, Steven L Portland, OR 21 809
McAuliffe, Daniel J Boxford, MA 7 205
Parrish, John A Boston, MA 9 250

Cited Art Landscape

  • No Cited Art to Display

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
NITTO DENKO CORPORATION (14)
5,885,211 Microporation of human skin for monitoring the concentration of an analyte 464 1997
6,173,202 Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue 70 1998
6,142,939 Microporation of human skin for drug delivery and monitoring applications 264 1998
6,183,434 Multiple mechanical microporation of skin or mucosa 114 1999
6,527,716 Microporation of tissue for delivery of bioactive agents 129 1999
6,508,785 Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue 130 2000
6,685,699 Self-removing energy absorbing structure for thermal tissue ablation 43 2002
7,392,080 Transdermal drug delivery patch system, method of making same and method of using same 28 2003
8,016,811 Method for transdermal delivery of permeant substances 0 2003
7,758,561 Microporation of tissue for delivery of bioactive agents 5 2004
8,116,860 Transdermal porator and patch system and method for using same 1 2008
8,706,210 Transdermal integrated actuator device, methods of making and using same 0 2009
8,517,958 Transdermal integrated actuator device, methods of making and using same 0 2010
8,641,689 Transdermal porator and patch system and method for using same 0 2011
 
ABBOTT LABORATORIES (13)
6,063,039 Method and apparatus for obtaining blood for diagnostic tests 254 1996
6,027,496 Removal of stratum corneum by means of light 50 1997
6,155,992 Method and apparatus for obtaining interstitial fluid for diagnostic tests 218 1997
6,093,156 Method and apparatus for obtaining blood for diagnostic tests 464 1997
6,027,459 Method and apparatus for obtaining blood for diagnostic tests 393 1997
6,569,157 Removal of stratum corneum by means of light 163 1998
6,077,660 Diagnostic assay requiring a small sample of biological fluid 62 1998
6,245,060 Removal of stratum corneum by means of light 153 1999
6,283,926 Method and apparatus for obtaining blood for diagnostic tests 249 2000
6,506,168 Apparatus and method for obtaining blood for diagnostic tests 260 2000
6,306,104 Method and apparatus for obtaining blood for diagnostic tests 423 2000
6,537,243 Device and method for obtaining interstitial fluid from a patient for diagnostic tests 120 2000
6,837,858 Method and apparatus for obtaining blood for diagnostic tests 256 2001
 
LENSAR, INC. (12)
8,262,646 System and method for providing the shaped structural weakening of the human lens with a laser 19 2006
8,500,723 Liquid filled index matching device for ophthalmic laser procedures 3 2009
8,480,659 Method and system for removal and replacement of lens material from the lens of an eye 2 2009
8,758,332 Laser system and method for performing and sealing corneal incisions in the eye 0 2010
8,617,146 Laser system and method for correction of induced astigmatism 3 2010
8,382,745 Laser system and method for astigmatic corrections in association with cataract treatment 8 2010
8,465,478 System and method for performing LADAR assisted procedures on the lens of an eye 3 2010
D695408 Laser system for treatment of the eye 2 2010
D694890 Laser system for treatment of the eye 2 2010
8,556,425 Purkinjie image-based alignment of suction ring in ophthalmic applications 3 2011
8,801,186 System and method of scan controlled illumination of structures within an eye 0 2011
8,708,491 Method and system for measuring an eye 0 2012
 
PALOMAR MEDICAL TECHNOLOGIES, LLC (9)
7,763,016 Light energy delivery head 3 2005
8,346,347 Skin optical characterization device 2 2006
7,942,915 Phototreatment device for use with coolants 4 2006
7,942,916 Phototreatment device for use with coolants and topical substances 8 2006
8,328,794 System for electromagnetic radiation dermatology and head for use therewith 0 2008
7,935,107 Heads for dermatology treatment 8 2010
8,002,768 Light energy delivery head 3 2010
8,109,924 Heads for dermatology treatment 0 2011
8,328,796 Light energy delivery head 0 2011
 
CARDIOFOCUS, INC. (6)
4,917,084 Infrared laser catheter system 162 1988
4,950,266 Infrared laser catheter system 65 1988
5,196,004 Infrared laser catheter system 84 1989
6,159,203 Infrared laser catheter system 37 1990
5,843,073 Infrared laser catheter system 64 1995
6,547,780 Infrared laser catheter system 56 1998
 
SYNERON MEDICAL LTD. (6)
6,615,079 Transdermal drug delivery and analyte extraction 17 2000
6,708,060 Handheld apparatus and method for transdermal drug delivery and analyte extraction 35 2001
6,611,706 Monopolar and bipolar current application for transdermal drug delivery and analyte extraction 86 2001
6,597,946 Electronic card for transdermal drug delivery and analyte extraction 36 2001
6,711,435 Transdermal drug delivery and analyte extraction 36 2001
7,164,942 Handheld apparatus and method for transdermal drug delivery and analyte extraction 45 2004
 
Transmedica International, Inc. (6)
5,643,252 Laser perforator 69 1993
5,839,446 Laser perforator 16 1997
6,315,772 Laser assisted pharmaceutical delivery and fluid removal 58 1997
6,251,100 Laser assisted topical anesthetic permeation 23 1997
6,056,738 Interstitial fluid monitoring 123 1997
6,387,059 Interstitial fluid monitoring 17 1999
 
SUDORMED, INC. (5)
5,438,984 Apparatus and method for the collection of analytes on a dermal patch 120 1993
5,465,713 Energy-assisted transdermal collection patch for accelerated analyte collection and method of use 15 1993
5,676,144 Method and apparatus for determination of chemical species in body fluid 16 1995
5,817,012 Method of determining an analyte 25 1997
5,944,662 Method and apparatus of determination of chemical species in perspiration 12 1998
 
DERMAL SYSTEMS INTERNATIONAL, INC. (3)
6,887,202 Systems and methods for monitoring health and delivering drugs transdermally 153 2001
7,931,592 Systems and methods for monitoring health and delivering drugs transdermally 11 2005
8,568,315 Systems and methods for monitoring health and delivering drugs transdermally 0 2011
 
FOS HOLDING S.A. (3)
7,156,859 Device for separating the epithelium layer from the surface of the cornea of an eye 3 2001
7,004,953 Device for separating the epithelium layer from the surface of the cornea of an eye 3 2002
7,708,750 Device for separating the epithelium layer from the surface of the cornea of an eye 0 2004
 
JOHNSON & JOHNSON CONSUMER COMPANIES, INC. (3)
6,855,117 Method of treating the skin of a subject 19 2001
6,840,910 Method of distributing skin care products 2 2001
6,790,179 Method of examining and diagnosing skin health 5 2001
 
LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (3)
6,022,309 Opto-acoustic thrombolysis 43 1996
5,944,687 Opto-acoustic transducer for medical applications 46 1996
6,379,325 Opto-acoustic transducer for medical applications 17 1999
 
RELIANT TECHNOLOGIES, INC. (3)
RE42594 Tissue cooling rod for laser surgery 1 2005
8,291,913 Adaptive control of optical pulses for laser medicine 0 2008
RE43881 Tissue cooling rod for laser surgery 0 2011
 
THERMAGE, INC. (3)
7,452,358 RF electrode assembly for handpiece 49 2003
7,481,809 Handpiece with RF electrode and non-volatile memory 18 2005
8,685,017 Method and kit for treatment of tissue 0 2007
 
DEPUY SYNTHES PRODUCTS, LLC (2)
8,092,529 Meniscus regeneration device 5 2002
7,871,440 Unitary surgical device and method 2 2006
 
GEORGIA TECH RESEARCH CORPORATION (2)
8,257,324 Microneedle drug delivery device 1 2007
8,708,966 Microneedle devices and methods of manufacture and use thereof 0 2010
 
LASER INDUSTRIES LTD. (2)
5,611,795 Laser facial rejuvenation 41 1995
5,807,386 Laser facial rejuvenation 9 1996
 
THE GENERAL HOSPITAL CORPORATION (2)
6,251,099 Compound delivery using impulse transients 34 1997
6,689,094 Compound delivery using impulse transients 2 2001
 
The United States of America as represented by the Secretary of the Army (2)
6,797,276 Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response 34 1999
7,378,097 Use of penetration enhancers and barrier disruption methods to enhance the immune response of antigen and adjuvant 0 2004
 
TOUCHTEK LABS, LLC (2)
8,364,228 Appartus and method for continuous real-time trace biomolecular sampling, analysis, and delivery 0 2005
8,333,874 Flexible apparatus and method for monitoring and delivery 1 2006
 
VALERITAS LLC (2)
6,743,211 Devices and methods for enhanced microneedle penetration of biological barriers 294 1999
7,226,439 Microneedle drug delivery device 28 2003
 
COLGATE-PALMOLIVE COMPANY (1)
6,827,942 Composition and method of use 0 2000
 
ECHO THERAPEUTICS, INC. (1)
8,386,027 Skin permeation device for analyte sensing or transdermal drug delivery 0 2008
 
INNOGENETICS N.V. (1)
6,329,138 Method for detection of the antibiotic resistance spectrum of mycobacterium species 6 1997
 
MICROLIN, L.C. (1)
5,785,688 Fluid delivery apparatus and method 140 1996
 
PALOMAR MEDICAL TECHNOLOGIES, INC. (1)
8,182,473 Cooling system for a photocosmetic device 4 2006
 
PANTEC BIOSOLUTIONS AG (1)
8,753,332 Laser device and method for ablating biological tissue 0 2008
 
Second Sight Laser Technologies, Inc. (1)
7,655,002 Lenticular refractive surgery of presbyopia, other refractive errors, and cataract retardation 23 2004
 
SMART TECHNOLOGIES INC. (1)
7,141,034 Transdermal drug delivery device, method of making same and method of using same 104 2003
 
SPECTRX, INC. (1)
6,679,841 Fluid collection and monitoring device 157 2001
 
UNITED STATES OF AMERICA, THE (1)
7,037,499 Adjuvant for transcutaneous immunization 7 1999
 
VALERITAS, INC. (1)
8,361,037 Microneedles, microneedle arrays, and systems and methods relating to same 0 2002
 
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (1)
8,435,791 Controlled laser treatment for non-invasive tissue alteration, treatment and diagnostics with minimal collateral damage 1 2003
 
Other [Check patent profile for assignment information] (1)
5,003,987 Method and apparatus for enhanced drug permeation of skin 55 1988