Non-human primate monoclonal antibodies and methods
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United States of America Patent
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Oct 11, 1988
Issued Date -
N/A
app pub date -
Aug 19, 1985
filing date -
Jan 6, 1984
priority date (Note) -
Expired
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Abstract
A stable trioma cell line capable of secreting a non-human primate monoclonal antibody specific against a selected antigen. An exemplary cell line secretes chimpanzee monoclonal antibody specific against an antigen associated with hepatitis nonA/nonB infection. The cell line is produced, in the method of the invention, by isolating lymphocytes from a primate immunized with the selected antigen, and immortalizing the lymphocytes by fusion with a stable, non-antibody-secreting murine myeloma/human hybridoma cell line having selected-for human characteristics. The trioma fusion products are selected for secretion of the desired antibody, which has a variety of diagnostic and/or therapeutic uses.
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